Withanolides as Potential Immunosuppressive Agents against RAW264.7 Cells from the Pericarps of Datura metel
نویسندگان
چکیده
منابع مشابه
Antiproliferative withanolides from Datura wrightii.
A new withanolide, named withawrightolide (1), and four known withanolides (2-5) were isolated from the aerial parts of Datura wrightii. The structure of compound 1 was elucidated through 2D NMR and other spectroscopic techniques. In addition, the structure of withametelin L (2) was confirmed by X-ray crystallographic analysis. Using MTS viability assays, withanolides 1-5 showed antiproliferati...
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Four new withanolides named dmetelins A-D (compounds 1-4), along with the known compound 7α,27-dihydroxy-1-oxo-witha-2,5,24-trienolide (5) were isolated from the leaves of Datura metel L. (Solanaceae). Their structures were elucidated on the basis of detailed analysis of 1D and 2D NMR and mass spectrometry data. All the compounds were evaluated for their inhibitory effects on lipopolysaccharide...
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The antimycotic potential of Datura metel (syn. Datura alba Nees.) was investigated in vitro against Ascochyta rabiei, the cause of chickpea blight disease. The pathogen was exposed to various n-hexane concentrations (1, 2, 3 and 4% w/v) of shoot and root extracts of D. metel using poisoning food technique. All the employed concentrations of both root and shoot extracts significantly suppressed...
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The antibacterial efficacy of crude aqueous and ethanol extracts leaf, stem bark and roots of Datura metel at 20mg/ml were assayed against eight clinical bacterial isolates (Streptococcus b hemolytic, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Bacillus cereus and Streptococcus dysenteriae) by well in agar method The leaf and stem bark of the plant wa...
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ژورنال
عنوان ژورنال: Natural Product Communications
سال: 2017
ISSN: 1934-578X,1555-9475
DOI: 10.1177/1934578x1701200705